Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Danielle Swaney
LAB HEAD: Nevan Krogan
PROVIDER: PXD022111 | Pride | 2021-04-22
REPOSITORIES: Pride
Chaikovsky Andrea C AC Li Chuan C Jeng Edwin E EE Loebell Samuel S Lee Myung Chang MC Murray Christopher W CW Cheng Ran R Demeter Janos J Swaney Danielle L DL Chen Si-Han SH Newton Billy W BW Johnson Jeffrey R JR Drainas Alexandros P AP Shue Yan Ting YT Seoane Jose A JA Srinivasan Preethi P He Andy A Yoshida Akihiro A Hipkins Susan Q SQ McCrea Edel E Poltorack Carson D CD Krogan Nevan J NJ Diehl J Alan JA Kong Christina C Jackson Peter K PK Curtis Christina C Petrov Dmitri A DA Bassik Michael C MC Winslow Monte M MM Sage Julien J
Nature 20210414 7856
The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication<sup>1</sup>. Increased levels of cyclin D promote cell division by activating cyclin-dependent kinases 4 and 6 (hereafter, CDK4/6), which in turn phosphorylate and inactivate the retinoblastoma tumour suppressor. Accordingly, increased levels and activity of cyclin D-CDK4/6 complexes are strongly linked to unch ...[more]