Dataset Information
NALCN crosslinking experiments by BS3 crosslinker
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture
SUBMITTER: 
Shan Feng
LAB HEAD: Shan Feng
PROVIDER: PXD022119 | Pride | 2020-12-04
REPOSITORIES: Pride
Publications
Structure of the human sodium leak channel NALCN in complex with FAM155A.
Nature communications 20201117 1
NALCN, a sodium leak channel expressed mainly in the central nervous system, is responsible for the resting Na<sup>+</sup> permeability that controls neuronal excitability. Dysfunctions of the NALCN channelosome, NALCN with several auxiliary subunits, are associated with a variety of human diseases. Here, we report the cryo-EM structure of human NALCN in complex with FAM155A at an overall resolution of 3.1 angstroms. FAM155A forms extensive interactions with the extracellular loops of NALCN that ...[more]
