Dataset Information
Secretome containing extracellular vesicles (EV) from cardiovascular progenitors (EV-CPC) vs the secretome containing EV from Fibroblasts (EV-FB)
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Heart, Cardiac Muscle Myoblast, Muscle Fibroblast
DISEASE(S): Heart Failure
SUBMITTER: 
Valentin SABATET
LAB HEAD: Damarys Loew
PROVIDER: PXD022129 | Pride | 2023-09-22
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Design.xls | Xls | |||
| Quantification_results.xls | Xls | |||
| X1317FD.msf | Msf | |||
| X1317FD.raw | Raw | |||
| X1318FD.msf | Msf |
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Publications
Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy.
Frontiers in cardiovascular medicine 20230707
<h4>Background</h4>Current treatments of chemotherapy-induced cardiomyopathy (CCM) are of limited efficacy. We assessed whether repeated intravenous injections of human extracellular vesicles from cardiac progenitor cells (EV-CPC) could represent a new therapeutic option and whether EV manufacturing according to a Good Manufacturing Practices (GMP)-compatible process did not impair their bioactivity.<h4>Methods</h4>Immuno-competent mice received intra-peritoneal injections (IP) of doxorubicin (D ...[more]
