Dataset Information

Secretome containing extracellular vesicles (EV) from cardiovascular progenitors (EV-CPC) vs the secretome containing EV from Fibroblasts (EV-FB)

ABSTRACT: Secretome containing extracellular vesicles (EV) seem to mediate the benefits of cell therapy for ischemic heart failure. Our project has the objective of comparing the secretome containing extracellular vesicles (EV) from cardiac progenitor cells (EV-CPC) vs the secretome containing EV from Fibroblasts (EV-FB) in order to stablish a protein cartography of EV-CPC and the biological pathways that they are involved. seem to mediate the benefits of cell therapy for ischemic heart failure. Our project has the objective of comparing the secretome containing extracellular vesicles (EV) from cardiac progenitor cells (EV-CPC) vs the secretome containing EV from Fibroblasts (EV-FB) in order to stablish a protein cartography of EV-CPC and the biological pathways that they are involved.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart, Cardiac Muscle Myoblast, Muscle Fibroblast

DISEASE(S): Heart Failure

SUBMITTER: Valentin SABATET

LAB HEAD: Damarys Loew

PROVIDER: PXD022129 | Pride | 2023-09-22

REPOSITORIES: Pride

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Publications

Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy.

Desgres Manon M Lima Correa Bruna B Petrusca Lorena L Autret Gwennhael G Pezzana Chloé C Marigny Céline C Guillas Chloé C Bellamy Valérie V Vilar José J Perier Marie-Cécile MC Dingli Florent F Loew Damarys D Humbert Camille C Larghero Jérôme J Churlaud Guillaume G Renault Nisa N Croisille Pierre P Hagège Albert A Silvestre Jean-Sébastien JS Menasché Philippe P

Frontiers in cardiovascular medicine 20230707

<h4>Background</h4>Current treatments of chemotherapy-induced cardiomyopathy (CCM) are of limited efficacy. We assessed whether repeated intravenous injections of human extracellular vesicles from cardiac progenitor cells (EV-CPC) could represent a new therapeutic option and whether EV manufacturing according to a Good Manufacturing Practices (GMP)-compatible process did not impair their bioactivity.<h4>Methods</h4>Immuno-competent mice received intra-peritoneal injections (IP) of doxorubicin (D ...[more]

PMID: 37485274

Dataset Information

Secretome containing extracellular vesicles (EV) from cardiovascular progenitors (EV-CPC) vs the secretome containing EV from Fibroblasts (EV-FB)

Publications

Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy.

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