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Col4a5 mouse glomerular extracellular matrix

ABSTRACT: Alport mouse model (Col4a5) have been submitted for proteomic analysis. Glomeruli have been isolated from mouse kidneys, extracellular matrix has been enriched and analysed by mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Franziska Lausecker

LAB HEAD: Rachel Lennon

PROVIDER: PXD022227 | Pride | 2022-08-12

REPOSITORIES: Pride

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Identification of an Altered Matrix Signature in Kidney Aging and Disease.

Randles Michael J MJ Lausecker Franziska F Kong Qingyang Q Suleiman Hani H Reid Graeme G Kolatsi-Joannou Maria M Davenport Bernard B Tian Pinyuan P Falcone Sara S Falcone Sara S Potter Paul P Van Agtmael Tom T Norman Jill T JT Long David A DA Humphries Martin J MJ Miner Jeffrey H JH Lennon Rachel R

Journal of the American Society of Nephrology : JASN 20210528 7

<h4>Background</h4>Accumulation of extracellular matrix in organs and tissues is a feature of both aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis accompany the decline in function, which current therapies cannot address, leading to organ failure. Although histologic and ultrastructural patterns of excess matrix form the basis of human disease classifications, a comprehensive molecular resolution of abnormal matrix is lacking.<h4>Methods</h4>Using mass spectr ...[more]

PMID: 34049963

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