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Effects of prenylcysteine oxidase 1 (PCYOX1) silencing on HepG2 cell secretome

ABSTRACT: We performed a label free mass spectrometry-based proteomic analysis to investigate the effects of PCYOX1 silencing on the secretome of human HepG2 cells

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Cell Culture

SUBMITTER: Maura Brioschi

LAB HEAD: Cristina banfi

PROVIDER: PXD022302 | Pride | 2021-10-12

REPOSITORIES: Pride

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Prenylcysteine oxidase 1, an emerging player in atherosclerosis.

Banfi C C Baetta R R Barbieri S S SS Brioschi M M Brioschi M M Guarino A A Ghilardi S S Sandrini L L Eligini S S Polvani G G Bergman O O Eriksson P P Tremoli E E

Communications biology 20210921 1

The research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. Here, we provided evidence that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), in the human atherosclerotic lesions, is both synthesized locally and transported within the subintimal space by proatherogenic lipoproteins accumulating in the arterial wall during atherogenes ...[more]

PMID: 34548610

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