Proteomics

Dataset Information

0

Fast skeletal myosin binding protein-C regulates fast skeletal muscle contraction


ABSTRACT: Myosin-binding protein C (MyBP-C) is a thick filament regulatory protein found exclusively in the C-zone of the A band in the sarcomeres of vertebrate striated muscle. Cardiac, slow skeletal and fast skeletal MyBP-C (fMyBP-C) paralogs perform different functions. However, the functional role of fMyBP-C in fast skeletal muscle is completely unknown. Genetic mutations in human fMyBP-C lead to skeletal myopathies. All three isoforms share similar protein structures, but likely differ substantially in terms of expression and function, which may serve the distinct physiologies of fast and slow muscle fibers. In the present study, we developed a novel fMyBP-C global knockout (KO) mouse model (C2-/-) to investigate the structural, functional, molecular, cellular and physiological roles of fMyBP-C in skeletal muscle.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Whole Body

SUBMITTER: Sheng Zhang  

LAB HEAD: Sheng Zhang

PROVIDER: PXD022316 | Pride | 2021-04-09

REPOSITORIES: Pride

Dataset's files

Source:

Similar Datasets

| PRJNA674604 | ENA
2014-03-04 | GSE55507 | GEO
2014-03-04 | E-GEOD-55507 | biostudies-arrayexpress
2014-01-01 | GSE43071 | GEO
2014-10-04 | GSE62028 | GEO
2020-11-30 | GSE160827 | GEO
2014-10-04 | E-GEOD-62028 | biostudies-arrayexpress
2014-04-27 | GSE46151 | GEO
2014-01-01 | E-GEOD-43071 | biostudies-arrayexpress
2007-01-18 | GSE6654 | GEO