Subcellular proteomics of murine ESC-derived neurons

ABSTRACT: We studied the effects of different stimuli on on the subcellular proteome of neurons differentiated from murine embryonic stem cells (ESC). We focused on the changes in the chromatin-bound fraction to elucidate specific differences in the gene regulatory machinery activated upon stimulation with Brain-derived neurotrophic factor (BDNF) or a general membrane-depolarization stimulus, potassium chloride (KCl).

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Neuron, Cell Culture

SUBMITTER: Henrik Hammarén  

LAB HEAD: Mikhail M Savitski

PROVIDER: PXD022378 | Pride | 2022-09-15

REPOSITORIES: Pride