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CFAP161 interactome from mouse testis

ABSTRACT: Identification of the interactome of the ciliary protein CFAP161 from mouse testit to identify the molecular function of this protein

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Sperm

DISEASE(S): Ciliopathy

SUBMITTER: Karsten Boldt

LAB HEAD: Dr. Karsten Boldt

PROVIDER: PXD022420 | Pride | 2021-09-09

REPOSITORIES: Pride

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The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus.

Beckers Anja A Fuhl Franziska F Ott Tim T Boldt Karsten K Brislinger Magdalena Maria MM Walentek Peter P Schuster-Gossler Karin K Hegermann Jan J Alten Leonie L Kremmer Elisabeth E Przykopanski Adina A Serth Katrin K Ueffing Marius M Blum Martin M Gossler Achim A

Scientific reports 20210625 1

Cilia are protrusions of the cell surface and composed of hundreds of proteins many of which are evolutionary and functionally well conserved. In cells assembling motile cilia the expression of numerous ciliary components is under the control of the transcription factor FOXJ1. Here, we analyse the evolutionary conserved FOXJ1 target CFAP161 in Xenopus and mouse. In both species Cfap161 expression correlates with the presence of motile cilia and depends on FOXJ1. Tagged CFAP161 localises to the b ...[more]

PMID: 34172766

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