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Proteinases in psoriatic arthritis

ABSTRACT: Characterize active synovial fluid (SF) serine proteinases in psoriatic arthritis (PsA) in comparison to osteoarthritis (OA) and rheumatoid arthritis (RA)

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Synovia

SUBMITTER: Omar Cruz

LAB HEAD: Vinod Chandran

PROVIDER: PXD022442 | Pride | 2021-03-29

REPOSITORIES: Pride

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Proteinase-Mediated Macrophage Signaling in Psoriatic Arthritis.

Abji Fatima F Rasti Mozhgan M Gómez-Aristizábal Alejandro A Muytjens Carla C Saifeddine Mahmoud M Mihara Koichiro K Motahhari Majid M Gandhi Rajiv R Viswanathan Sowmya S Hollenberg Morley D MD Oikonomopoulou Katerina K Chandran Vinod V

Frontiers in immunology 20210308

<h4>Objective</h4>Multiple proteinases are present in the synovial fluid (SF) of an arthritic joint. We aimed to identify inflammatory cell populations present in psoriatic arthritis (PsA) SF compared to osteoarthritis (OA) and rheumatoid arthritis (RA), identify their proteinase-activated receptor 2 (PAR2) signaling function and characterize potentially active SF serine proteinases that may be PAR2 activators.<h4>Methods</h4>Flow cytometry was used to characterize SF cells from PsA, RA, OA pati ...[more]

PMID: 33763056

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