Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain
SUBMITTER: 
Sandra Anjo
LAB HEAD: Hugo Almeida
PROVIDER: PXD022478 | Pride | 2021-04-27
REPOSITORIES: Pride
Publications
Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system.
Guimarães Marco Rafael MR Anjo Sandra Isabel SI Cunha Ana Margarida AM Esteves Madalena M Sousa Nuno N Almeida Armando A Manadas Bruno B Leite-Almeida Hugo H
Pain 20210601 6
<h4>Abstract</h4>It remains unknown why on similar acute/subacute painful conditions, pain persists in some individuals while in others it resolves. Genetic factors, mood, and functional alterations, particularly involving the mesolimbic network, seem to be key. To explore potential susceptibility or resistance factors, we screened a large population of rats with a peripheral neuropathy and we isolated a small subset (<15%) that presented high thresholds (HTs) to mechanical allodynia (reduced pa ...[more]
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