Identification of chromatin-associated proteins occupying the promoter region of CDKN1A

ABSTRACT: The p21 protein, encoded by CDKN1A, plays a vital role in the induction of senescence, and its transcriptional control by p53 tumour supressor is well-established. However, p21 can also be regulated in a p53-independent manner, by mechanisms that remain poorly understood. Therefore, we here used a chromatin-directed proteomic approach and identified ZNF84 as a novel regulator of p21 in various p53-deficient cell lines.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Mahmoudreza Rafiee  

LAB HEAD: Jeroen Krijgsveld

PROVIDER: PXD022542 | Pride | 2021-09-07

REPOSITORIES: Pride