Proteomic analysis of ARPE-19 cells exposed to chronic H2O2 treatment

ABSTRACT: We performed a proteomic analysis of a retinal pigment epithelium cell line (ARPE-19) exposed to long-term sublethal levels of H2O2 to mimic low-level pro-oxidative insult in age-related macular degeneration (AMD). using a wide range of biochemical analyses and cell culture techniques, we highlighted changes in energy metabolism, extracellular matrix organization and inflammation-related processes, which may help in understanding the molecular pathogenesis of AMD.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Retinal Pigment Epithelial Cell, Cell Culture

DISEASE(S): Age Related Macular Degeneration

SUBMITTER: Davide Chiasserini  

LAB HEAD: Davide Chiasserini

PROVIDER: PXD022545 | Pride | 2021-01-04

REPOSITORIES: Pride