Quantitative proteome of urinary extracellular vesicles (uEVs) from hypertensive patients with raised aldosterone-to-renin ratios (ARRs) that underwent seated saline suppression testing (SSST)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Urine
SUBMITTER: 
Qi Wu
LAB HEAD: Robert A. Fenton
PROVIDER: PXD022653 | Pride | 2022-10-13
REPOSITORIES: Pride
Publications
Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles.
Wu Aihua A Wolley Martin J MJ Wu Qi Q Cowley Diane D Palmfeldt Johan J Welling Paul A PA Fenton Robert A RA Stowasser Michael M
Kidney360 20220301 5
<h4>Background</h4>Sodium chloride (NaCl) loading and volume expansion suppress the renin-angiotensin-aldosterone system to reduce renal tubular reabsorption of NaCl and water, but effects on the sodium-chloride cotransporter (NCC) and relevant renal transmembrane proteins that are responsible for this modulation in humans are less well investigated.<h4>Methods</h4>We used urinary extracellular vesicles (uEVs) as an indirect readout to assess renal transmembrane proteins involved in NaCl and wat ...[more]
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