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The distinct N-terminomes of Bothrops jararaca newborn and adult venoms.

ABSTRACT: In this study we applied the Terminal Amine Isotopic Labeling of Substrates (TAILS) technology to characterize the natural N-terminome of newborn and adult Bothrops jararaca venoms.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Bothrops Jararaca (jararaca) (bothrops Jajaraca)

SUBMITTER: Debora Andrade Silva

LAB HEAD: Solange Maria de Toledo Serrano

PROVIDER: PXD022696 | Pride | 2021-05-15

REPOSITORIES: Pride

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The distinct N-terminomes of Bothrops jararaca newborn and adult venoms.

Andrade-Silva Débora D Nishiyama Milton Y MY Stuginski Daniel R DR Zelanis André A Serrano Solange M T SMT

Biochimica et biophysica acta. Proteins and proteomics 20210313 7

Using approaches of transcriptomics and proteomics we have shown that the phenotype of Bothrops jararaca venom undergoes a significant rearrangement upon neonate to adult transition. Most regulatory processes in biology are intrinsically related to modifications of protein structure, function, and abundance. However, it is unclear to which extent intrinsic proteolysis affects toxins and snake venom phenotypes upon ontogenesis. Here we assessed the natural N-terminome of Bothrops jararaca newborn ...[more]

PMID: 33722654

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