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Mouse DRG incision injury versus sham_DIA-MS

ABSTRACT: Acute pain after surgery is still managed insufficiently. One major need is, therefore, the identification of new targets specifically relevant for postoperative pain to develop effective and non-addictive analgesics. To this end, we have used the plantar incision model in male mice and DIA-MS to reveal unprecedented insights into proteome dynamics in dorsal root ganglia (DRG) 24 hours after incision.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spinal Ganglion

SUBMITTER: Christin Kappert

LAB HEAD: Manuela Schmidt

PROVIDER: PXD022706 | Pride | 2021-09-09

REPOSITORIES: Pride

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A proteome signature for acute incisional pain in dorsal root ganglia of mice.

Pogatzki-Zahn Esther M EM Gomez-Varela David D Erdmann Gerrit G Kaschube Katharina K Segelcke Daniel D Schmidt Manuela M

Pain 20210701 7

<h4>Abstract</h4>After surgery, acute pain is still managed insufficiently and may lead to short-term and long-term complications including chronic postsurgical pain and an increased prescription of opioids. Thus, identifying new targets specifically implicated in postoperative pain is of utmost importance to develop effective and nonaddictive analgesics. Here, we used an integrated and multimethod workflow to reveal unprecedented insights into proteome dynamics in dorsal root ganglia (DRG) of m ...[more]

PMID: 33492035

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