Name: human plasma sample parallel reaction monitoring
Keywords: Cervical cancer

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Human plasma sample parallel reaction monitoring

ABSTRACT: Women are vulnerable to cervical diseases including normal control, HSIL and early stage cervical carcinoma . The parallel reaction monitoring mass spectrometry (PRM-MS) were used to qualitatively and quantitatively analyze the candidate differential proteins identified in our previous studies and to link them with HPV status. The integration of HPV status with candidate serum markers is expected to efficiently narrow down the high risk population and provide sufficient clinical information for early diagnosis and effective therapy.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Cervix Carcinoma

SUBMITTER: Xiaona Chen

LAB HEAD: Xia Guo

PROVIDER: PXD022756 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer.

Hao Yi Y Ye Ming M Chen Xiaona X Zhao Hongli H Hasim Ayshamgul A Guo Xia X

Cancer cell international 20210218 1

<h4>Background</h4>To validate markers for cervical carcinoma (CC) and precancerous lesions related with HPV infections.<h4>Methods</h4>Three different cervical cancer cell lines C-33A, SiHa and Caski were used for secretome profiling by label-free quantitative proteomics. Cervical exfoliated cells and matching serum samples were collected from 284 patients with normal control (n = 75, 26.41 %), precancerous lesions (n = 88, 30.99 %) and early stage cervical squamous carcinoma (n = 121, 42.61 %) ...[more]

PMID: 33602229

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