Dataset Information

Chicken liver TMT-based proteomics

ABSTRACT: In order to investigate the chicken SLCO1B3 gene functin on the liver metabolism, we used the Yimeng blue eggshell and brown eggshell chickens as the chicken liver SLCO1B3 gene knock-down animal to do the proteomic analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Liver

SUBMITTER: Jianfei Chen

LAB HEAD: Xuemei Deng

PROVIDER: PXD022768 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

An EAV-HP insertion in the promoter region of SLCO1B3 has pleiotropic effects on chicken liver metabolism based on the transcriptome and proteome analysis.

Chen Jianfei J Hua Guoying G Han Deping D Zheng Xiaotong X Dong Xianggui X Wang Shuxiang S Long Junjiang J Zheng Zhonghua Z Wang Ailing A Wang Jiankui J Wang Xiaotong X Deng Xuemei X

Scientific reports 20210407 1

Solute carrier organic anion transporter 1B3 (SLCO1B3) is an important liver primarily highly expressed gene, its encoded protein (OATP1B3) involved in the transport of multi-specific endogenous and exogenous substances. We previously reported that an EAV-HP inserted mutation (IM+) in the 5' flanking region of SLCO1B3 was the causative mutation of chicken blue eggs, and a further research showed that IM+ significantly reduced the expression of SLCO1B3 in liver. Herein, we confirmed a cholate res ...[more]

PMID: 33828143

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Dataset Information

Chicken liver TMT-based proteomics

Publications

An EAV-HP insertion in the promoter region of SLCO1B3 has pleiotropic effects on chicken liver metabolism based on the transcriptome and proteome analysis.

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