Dataset Information

Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients

ABSTRACT: The relationship between the microbial changes with clinical-pathological outcomes are still far from being conclusive. Herein, we investigate the ability of metagenomics (MG) and metaproteomics (MP) saliva data in distinguishing C, L0 and L1 patients. For that, we combined two strategies using MG analysis using 16S rDNA sequencing of saliva cells, and MP analysis using liquid chromatography tandem mass spectrometry of saliva supernatant and cells.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

SUBMITTER: Adriana Franco Paes Leme

LAB HEAD: Adriana Franco Paes Leme

PROVIDER: PXD022859 | Pride | 2022-11-09

REPOSITORIES: Pride

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Publications

Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients.

Granato Daniela C DC Neves Leandro X LX Trino Luciana D LD Carnielli Carolina M CM Lopes Ariane F B AFB Yokoo Sami S Pauletti Bianca A BA Domingues Romênia R RR Sá Jamile O JO Persinoti Gabriella G Paixão Douglas A A DAA Rivera César C de Sá Patroni Fabio M FM Tommazetto Geizecler G Santos-Silva Alan R AR Lopes Márcio A MA de Castro Gilberto G Brandão Thaís B TB Prado-Ribeiro Ana Carolina AC Squina Fabio M FM Telles Guilherme P GP Paes Leme Adriana F AF

Biochimica et biophysica acta. Proteins and proteomics 20210409 8

Saliva is a biofluid that maintains the health of oral tissues and the homeostasis of oral microbiota. Studies have demonstrated that Oral squamous cell carcinoma (OSCC) patients have different salivary microbiota than healthy individuals. However, the relationship between these microbial differences and clinicopathological outcomes is still far from conclusive. Herein, we investigate the capability of using metagenomic and metaproteomic saliva profiles to distinguish between Control (C), OSCC w ...[more]

PMID: 33839314

Dataset Information

Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients

Publications

Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients.

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