Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Leukocyte, Cell Culture
SUBMITTER: Evelyn Ramberger
LAB HEAD: Philipp Mertins
PROVIDER: PXD022903 | Pride | 2021-07-12
REPOSITORIES: Pride
Ramberger Evelyn E Sapozhnikova Valeria V Kowenz-Leutz Elisabeth E Zimmermann Karin K Nicot Nathalie N Nazarov Petr V PV Perez-Hernandez Daniel D Reimer Ulf U Mertins Philipp P Dittmar Gunnar G Leutz Achim A
iScience 20210604 6
C/EBPα represents a paradigm intrinsically disordered transcription factor containing short linear motifs and post-translational modifications (PTM). Unraveling C/EBPα protein interaction networks is a prerequisite for understanding the multi-modal functions of C/EBPα in hematopoiesis and leukemia. Here, we combined arrayed peptide matrix screening (PRISMA) with BioID to generate an <i>in vivo</i> validated and isoform specific interaction map of C/EBPα. The myeloid C/EBPα interactome comprises ...[more]