Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Amniotic Fluid, Embryonic Stem Cell
DISEASE(S): Cakut
SUBMITTER: Mylène CAMUS
LAB HEAD: Joost-Peter Schanstra
PROVIDER: PXD022926 | Pride | 2023-09-26
REPOSITORIES: Pride
Fédou Camille C Camus Mylène M Lescat Ophélie O Feuillet Guylène G Mueller Ilka I Ross Bryony B Buléon Marie M Neau Eric E Alves Melinda M Goudounéche Dominique D Breuil Benjamin B Boizard Franck F Bardou Quentin Q Casemayou Audrey A Tack Ivan I Dreux Sophie S Batut Julie J Blader Patrick P Burlet-Schiltz Odile O Decramer Stéphane S Wirth Brunhilde B Klein Julie J Saulnier-Blache Jean Sébastien JS Buffin-Meyer Bénédicte B Schanstra Joost P JP
The Journal of pathology 20210616 5
Congenital anomalies of the kidney and the urinary tract (CAKUT) are the first cause of chronic kidney disease in childhood. Several genetic and environmental origins are associated with CAKUT, but most pathogenic pathways remain elusive. Considering the amniotic fluid (AF) composition as a proxy for fetal kidney development, we analyzed the AF proteome from non-severe CAKUT (n = 19), severe CAKUT (n = 14), and healthy control (n = 22) fetuses using LC-MS/MS. We identified 471 significant protei ...[more]