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Temperature induced change of the HLA ligandome

ABSTRACT: Temperature induced change of the HLA ligandome and proteome in B-cells

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Cell Suspension Culture

SUBMITTER: Laura Demmers

LAB HEAD: Wei Wu

PROVIDER: PXD022930 | Pride | 2021-05-07

REPOSITORIES: pride

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Publications

HLA Class II Presentation Is Specifically Altered at Elevated Temperatures in the B-Lymphoblastic Cell Line JY.

Demmers Laura C LC Wu Wei W Heck Albert J R AJR

Molecular & cellular proteomics : MCP 20210429

Human leukocyte antigen (HLA) molecules play critical roles in our adaptive immune system by signaling a cell's health status to the immune system, through presentation of small peptides. Understanding HLA biology is important because of its prominent role in autoimmune diseases and cancer immunotherapy. Although both the HLA class I and class II antigen processing and presentation pathways have been studied extensively, the fundamental rules in HLA class II antigen presentation still remain les ...[more]

PMID: 33933681

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