Proteomics

Dataset Information

0

Quantitative Phosphoproteomics for Prolonged Cabozantinib-Treated Renal Cell Carcinoma Cells


ABSTRACT: Patients with recurrent or metastatic renal cell carcinoma (mRCC) usually develop resistance to targeted tyrosine kinase inhibitors (TKI). Recently, FDA-approved cabozantinib is found to inhibit pathways linked to TKI resistance. Although cabozantinib is believed to be a new gold standard in managing TKI-resistant mRCC, it is still possible that mRCC can develop resistance to prolonged cabozantinib treatment by changing intracellular phosphorylation dynamics. In this study, 786-O was used for prolonged cabozantinib treatment for more than 4 months. Using quantitative phosphoproteomic approach, we tried to identified dysregulated pathways in prolonged cabozantinib treatment

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Wei-Chi Ku  

LAB HEAD: Wei-Chi Ku

PROVIDER: PXD022957 | Pride | 2026-03-03

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
18091801_786O-P-cabo-1-1_1.raw Raw
18091802_786O-P-cabo-1-1_2.raw Raw
18091803_786O-P-cabo-1-2_1.raw Raw
18091804_786O-P-cabo-1-2_2.raw Raw
18091805_786O-P-cabo-1-3_1.raw Raw
Items per page:
1 - 5 of 49

Similar Datasets

2026-02-25 | GSE234724 | GEO
2014-02-04 | E-GEOD-54621 | biostudies-arrayexpress
2014-02-04 | GSE54621 | GEO
2016-08-23 | E-GEOD-74575 | biostudies-arrayexpress
2014-08-30 | E-GEOD-60939 | biostudies-arrayexpress
2016-08-23 | GSE74575 | GEO
2021-03-11 | PXD020108 | Pride
2024-01-22 | GSE253478 | GEO
2018-10-02 | PXD008454 | Pride
2014-08-30 | GSE60939 | GEO