Quantitative Phosphoproteomics for Prolonged Cabozantinib-Treated Renal Cell Carcinoma Cells

ABSTRACT: Patients with recurrent or metastatic renal cell carcinoma (mRCC) usually develop resistance to targeted tyrosine kinase inhibitors (TKI). Recently, FDA-approved cabozantinib is found to inhibit pathways linked to TKI resistance. Although cabozantinib is believed to be a new gold standard in managing TKI-resistant mRCC, it is still possible that mRCC can develop resistance to prolonged cabozantinib treatment by changing intracellular phosphorylation dynamics. In this study, 786-O was used for prolonged cabozantinib treatment for more than 4 months. Using quantitative phosphoproteomic approach, we tried to identified dysregulated pathways in prolonged cabozantinib treatment

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Wei-Chi Ku  

LAB HEAD: Wei-Chi Ku

PROVIDER: PXD022957 | Pride | 2026-03-03

REPOSITORIES: Pride