Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Breast Cancer
SUBMITTER: Dupuy Jean-William
LAB HEAD: Jerome Devy
PROVIDER: PXD022978 | Pride | 2022-02-16
REPOSITORIES: Pride
Biomedicines 20211009 10
<h4>Background</h4>LRP-1 is a multifunctional scavenger receptor belonging to the LDLR family. Due to its capacity to control pericellular levels of various growth factors and proteases, LRP-1 plays a crucial role in membrane proteome dynamics, which appears decisive for tumor progression.<h4>Methods</h4>LRP-1 involvement in a TNBC model was assessed using an RNA interference strategy in MDA-MB-231 cells. In vivo, tumorigenic and angiogenic effects of LRP-1-repressed cells were evaluated using a ...[more]