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The immunopeptidome of HLA-DR from PBMC

ABSTRACT: Quantifiying the impact of initial cell counts on the identified HLA-DR immunopeptidome of PBMC.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Disease Free

SUBMITTER: Hesham ElAbd

LAB HEAD: Prof. Dr. Andreas Tholey

PROVIDER: PXD023032 | Pride | 2021-08-23

REPOSITORIES: Pride

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Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data.

ElAbd Hesham H Degenhardt Frauke F Koudelka Tomas T Kamps Ann-Kristin AK Tholey Andreas A Bacher Petra P Lenz Tobias L TL Franke Andre A Wendorff Mareike M

BMC bioinformatics 20210817 1

<h4>Background</h4>The human leukocyte antigen (HLA) proteins play a fundamental role in the adaptive immune system as they present peptides to T cells. Mass-spectrometry-based immunopeptidomics is a promising and powerful tool for characterizing the immunopeptidomic landscape of HLA proteins, that is the peptides presented on HLA proteins. Despite the growing interest in the technology, and the recent rise of immunopeptidomics-specific identification pipelines, there is still a gap in data-anal ...[more]

PMID: 34404349

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