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Long term intrathecal administration of morphine vs baclofen: differences in CSF identified using multi-glycomics

ABSTRACT: CSF samples from patients that had long-term (>2years), intrathecal morphine or baclofen administered via an indwelling pump, and we performed proteomics and multi-glycomics via sequential release of polysialic acids, glycosaminoglycans, N-glycans and O-glycans from the same sample material.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Chronic Pain

SUBMITTER: Edward Moh

LAB HEAD: Nicolle H Packer

PROVIDER: PXD023111 | Pride | 2023-10-10

REPOSITORIES: Pride

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Long-term intrathecal administration of morphine vs. baclofen: Differences in CSF glycoconjugate profiles using multiglycomics.

Moh Edward S X ESX Nishtala Krishnatej K Iqbal Sameera S Staikopoulos Vasiliki V Kapur Dilip D Hutchinson Mark R MR Packer Nicolle H NH

Glycobiology 20220201 1

Opioid use for treatment of persistent pain has increased dramatically over the past two decades, but it has not resulted in improved pain management outcomes. To understand the molecular mechanisms of opioids, molecular signatures that arise from opioid exposure are often sought after, using various analytical methods. In this study, we performed proteomics, and multiglycomics via sequential analysis of polysialic acids, glycosaminoglycans, N-glycans and O-glycans, using the same cerebral spina ...[more]

PMID: 34969075

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