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A wolf in another wolf’s clothing: Post-genomic regulation dictates venom profiles of medically-important cryptic kraits in India

ABSTRACT: This study investigates the widespread cryptic Bungarus caeruleus (Comman krait) in India and clinical repercussions of their bits by implementing multidisciplinary approach involving proteomics, transcripomics, and assessment of toxicity and efficacy of currently marketed anivenoms. The study also aims at understanding the evolutionary relationships between these phenotypically simillar kraits.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Bungarus

TISSUE(S): Venom

SUBMITTER: Kartik Sunagar

LAB HEAD: Dr. Kartik Sunagar

PROVIDER: PXD023127 | Pride | 2021-09-09

REPOSITORIES: Pride

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A Wolf in Another Wolf's Clothing: Post-Genomic Regulation Dictates Venom Profiles of Medically-Important Cryptic Kraits in India.

Sunagar Kartik K Khochare Suyog S Senji Laxme R R RR Attarde Saurabh S Dam Paulomi P Suranse Vivek V Khaire Anil A Martin Gerard G Captain Ashok A

Toxins 20210119 1

The Common Krait (Bungarus caeruleus) shares a distribution range with many other 'phenotypically-similar' kraits across the Indian subcontinent. Despite several reports of fatal envenomings by other Bungarus species, commercial Indian antivenoms are only manufactured against B. caeruleus. It is, therefore, imperative to understand the distribution of genetically distinct lineages of kraits, the compositional differences in their venoms, and the consequent impact of venom va ...[more]

PMID: 33477742

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