N-terminal VP1 truncation favor T=1 norovirus-like particles

ABSTRACT: Noroviruses cause immense sporadic gastroenteritis outbreaks worldwide. Upcoming genotypes, which are divided based on VP1 sequence, further enhance this public thread regularly. Self-assembling properties of the human norovirus major capsid protein VP1 are crucial for using virus-like particles (VLPs) for vaccine development. However, there is no vaccine available yet. Here, VLPs from different variants produced in insect cells are characterized in detail using a set of biophysical and structural tools.

INSTRUMENT(S):

ORGANISM(S): Norovirus

SUBMITTER: Christoph Krisp  

LAB HEAD: Dr Charlotte Uetrecht

PROVIDER: PXD023182 | Pride | 2021-01-11

REPOSITORIES: Pride