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Comprehensive analysis of the host-virus interactome of SARS-CoV-2

ABSTRACT: Host-virus protein-protein interaction is the key component of SARS-CoV-2 life cycle, which can be targeted for therapeutic intervention. Thus, we conducted a comprehensive interactome study between the virus and host cell using tandem affinity purification (TAP) and BioID2 labeling strategies. In addition, we compared the interactomes of two key SARS-CoV-2 encoded viral proteins, NSP1 and N protein, to the interactomes of their counterparts in other human coronaviruses.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Early Embryonic Cell

SUBMITTER: Zhen Chen

LAB HEAD: Junjie Chen

PROVIDER: PXD023209 | Pride | 2021-06-29

REPOSITORIES: Pride

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