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Mass spectrometry analysis of proteins interacting with STC1

ABSTRACT: identify the potential partners of STC1 at the protein level, we performed mass spectrometry on B16-F10 tumor cells stably expressing FLAG-tagged STC1.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Heng Lin

LAB HEAD: Weiping Zou

PROVIDER: PXD023251 | Pride | 2020-12-23

REPOSITORIES: Pride

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Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance.

Lin Heng H Kryczek Ilona I Li Shasha S Green Michael D MD Ali Alicia A Hamasha Reema R Wei Shuang S Vatan Linda L Szeliga Wojciech W Grove Sara S Li Xiong X Li Jing J Wang Weichao W Yan Yijian Y Choi Jae Eun JE Li Gaopeng G Bian Yingjie Y Xu Ying Y Zhou Jiajia J Yu Jiali J Xia Houjun H Wang Weimin W Alva Ajjai A Chinnaiyan Arul M AM Cieslik Marcin M Zou Weiping W

Cancer cell 20210128 4

Immunotherapy induces durable clinical responses in a fraction of patients with cancer. However, therapeutic resistance poses a major challenge to current immunotherapies. Here, we identify that expression of tumor stanniocalcin 1 (STC1) correlates with immunotherapy efficacy and is negatively associated with patient survival across diverse cancer types. Gain- and loss-of-function experiments demonstrate that tumor STC1 supports tumor progression and enables tumor resistance to checkpoint blocka ...[more]

PMID: 33513345

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