Drosophila yellow-h, dopaminechrome tautomerase
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Embryo
SUBMITTER: 
Alexey Veraksa
LAB HEAD: Manickam Sugumaran
PROVIDER: PXD023295 | Pride | 2023-01-17
REPOSITORIES: Pride
Publications
Drosophila yellow-h encodes dopaminechrome tautomerase: A new enzyme in the eumelanin biosynthetic pathway.
Barek Hanine H Zhao Heya H Heath Katerina K Veraksa Alexey A Sugumaran Manickam M
Pigment cell & melanoma research 20210825 1
Melanin is a widely distributed phenolic pigment that is biosynthesized from tyrosine and its hydroxylated product, dopa, in all animals. However, recent studies reveal a significant deviation from this paradigm, as insects appear to use dopamine rather than dopa as the major precursor of melanin. This observation calls for a reconsideration of the insect melanogenic pathway. While phenoloxidases and laccases can oxidize dopamine for dopaminechrome production, the fate of dopaminechrome remains ...[more]
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