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Renal cell carcinoma: a proteomic approach

ABSTRACT: The proteome of clinical tissue samples diagnosed with clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC) were evaluated analyzed along with the dataset identifier PXD022018 to establish a potential discriminative biomarker panel of proteins for these tumors subtypes.

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

DISEASE(S): Chromophobe Renal Cell Carcinoma,Renal Clear Cell Carcinoma,Renal Oncocytoma,Papillary Renal Cell Carcinoma

SUBMITTER: Hugo M. Santos

LAB HEAD: Hugo M. Santos

PROVIDER: PXD023296 | Pride | 2021-12-15

REPOSITORIES: Pride

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Absolute quantitative proteomics using the total protein approach to identify novel clinical immunohistochemical markers in renal neoplasms.

Jorge Susana S Capelo José L JL LaFramboise William W Satturwar Swati S Korentzelos Dimitrios D Bastacky Sheldon S Quiroga-Garza Gabriela G Dhir Rajiv R Wiśniewski Jacek R JR Lodeiro Carlos C Santos Hugo M HM

BMC medicine 20210906 1

<h4>Background</h4>Renal neoplasms encompass a variety of malignant and benign tumors, including many with shared characteristics. The diagnosis of these renal neoplasms remains challenging with currently available tools. In this work, we demonstrate the total protein approach (TPA) based on high-resolution mass spectrometry (MS) as a tool to improve the accuracy of renal neoplasm diagnosis.<h4>Methods</h4>Frozen tissue biopsies of human renal tissues [clear cell renal cell carcinoma (n = 7), pa ...[more]

PMID: 34482820

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