Tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway

ABSTRACT: By precisely dissected MS for proteomics, we found that donepezil remarkably restored (at high dose), even elevated (at low dose) the level of vacuolar protein sorting-associated protein 37D (VP37D), an autophagy-related protein, in hTauMS mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: haitao Yu  

LAB HEAD: Jian-zhi Wang

PROVIDER: PXD023297 | Pride | 2021-09-09

REPOSITORIES: Pride