Dataset Information
Tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: 
haitao Yu
LAB HEAD: Jian-zhi Wang
PROVIDER: PXD023297 | Pride | 2021-09-09
REPOSITORIES: Pride
Dataset's files
Publications
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Clinical and translational medicine 20210601 6
Tau accumulation and cholinergic impairment are characteristic pathologies in Alzheimer's disease (AD). However, the causal role of tau accumulation in cholinergic lesion is elusive. Here, we observed an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in their cholinergic neurons. Overexpressing hTau in mouse MS (MS<sup>hTau</sup> ) for 6 months but not 3 months induced spatial memory impairment without changing object recognition and anxiety-like behavior, ...[more]
