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Gas plasma combined with antibiotics for the eradication of methicillin-resistant Staphylococcus aureus biofilm

ABSTRACT: Gas plasma treatment caused polymerization of the SaClpP proteins and loss of protein function due to the oxidative modifications induced by reactive oxygen species of the gas plasma.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Staphylococcus Aureus (strain Col)

SUBMITTER: Li Guo

LAB HEAD: Dingxin Liu

PROVIDER: PXD023352 | Pride | 2021-09-09

REPOSITORIES: Pride

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Cold Atmospheric-Pressure Plasma Caused Protein Damage in Methicillin-Resistant Staphylococcus aureus Cells in Biofilms.

Guo Li L Yang Lu L Qi Yu Y Niyazi Gulimire G Huang Lingling L Gou Lu L Wang Zifeng Z Zhang Lei L Liu Dingxin D Wang Xiaohua X Chen Hailan H Kong Michael G MG

Microorganisms 20210517 5

Biofilms formed by multidrug-resistant bacteria are a major cause of hospital-acquired infections. Cold atmospheric-pressure plasma (CAP) is attractive for sterilization, especially to disrupt biofilms formed by multidrug-resistant bacteria. However, the underlying molecular mechanism is not clear. In this study, CAP effectively reduced the living cells in the biofilms formed by methicillin-resistant Staphylococcus aureus, and 6 min treatment with CAP reduced the S. aureus cells in ...[more]

PMID: 34067642

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