Dataset Information
Nanobodies peptide/glycopeptide identification
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Lama Glama
SUBMITTER: 
Nichollas Scott
LAB HEAD: Associate Professor Wai-Hong Tham
PROVIDER: PXD023483 | Pride | 2021-09-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Nsco_1482_WHT_Byonic.zip | Other | |||
| Nsco_1482_WHT_WNB_15_FC.raw | Raw | |||
| Nsco_1482_WHT_WNB_2_FC.raw | Raw | |||
| Nsco_1482_WHT_WNB_36_FC.raw | Raw | |||
| Nsco_1482_WHT_WNB_7_FC.raw | Raw |
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Publications
Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
Proceedings of the National Academy of Sciences of the United States of America 20210501 19
Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVID-19. Here, we identified high-affinity nanobodies from alpacas immunized with coronavirus spike and receptor-binding domains (RBD) that disrupted RBD engagement with the human receptor angiotensin-converting enzyme 2 (ACE2) and potently neutralized SARS-CoV-2. Epitope mapping, X-ray crystallography, and cryo-electron microscopy revealed two distinct antigenic sites a ...[more]