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LinX - software for evaluation of CX-MS data

ABSTRACT: Chemical cross-linking mass spectrometry data from analysis of N14/N15 labeled proteins

INSTRUMENT(S): ultraflex

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

SUBMITTER: Zdenek Kukacka

LAB HEAD: Petr Novak

PROVIDER: PXD023522 | Pride | 2021-03-11

REPOSITORIES: Pride

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LinX: A Software Tool for Uncommon Cross-Linking Chemistry.

Kukačka Zdeněk Z Rosůlek Michal M Jelínek Jan J Slavata Lukáš L Kavan Daniel D Novák Petr P

Journal of proteome research 20210303 4

Chemical cross-linking mass spectrometry has become a popular tool in structural biology. Although several algorithms exist that efficiently analyze data-dependent mass spectrometric data, the algorithm to identify and quantify intermolecular cross-links located at the interaction interface of homodimer molecules was missing. The algorithm in LinX utilizes high mass accuracy for ion identification. In contrast with standard data-dependent analysis, LinX enables the elucidation of cross-linked pe ...[more]

PMID: 33657806

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