Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF, Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Li Wang
LAB HEAD: Jenny PY Ting
PROVIDER: PXD023565 | Pride | 2022-02-16
REPOSITORIES: Pride
Guo Haitao H Wang Qi Q Ghneim Khader K Wang Li L Rampanelli Elena E Holley-Guthrie Elizabeth E Cheng Liang L Garrido Carolina C Margolis David M DM Eller Leigh A LA Robb Merlin L ML Sekaly Rafick-Pierre RP Chen Xian X Su Lishan L Ting Jenny P-Y JP
Nature immunology 20210325 4
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4<sup>+</sup> T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4<sup>+</sup> T cells from patients with HIV-1 and revealed that the elevated oxidative phosphorylation (OXPHOS) pathway is associated with poor outcomes. Inhibition of OXPHOS by the US Food and Drug Administration-approved drug metformin, which targets mitochondrial respiratory chain ...[more]