Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Dendritic Cell
DISEASE(S): Disease Of Metabolism
SUBMITTER: Cristina Clement
LAB HEAD: Laura Santambrogio and Lawrence J.Stern
PROVIDER: PXD023581 | Pride | 2021-03-21
REPOSITORIES: Pride
Clement Cristina C CC Nanaware Padma P PP Yamazaki Takahiro T Negroni Maria Pia MP Ramesh Karthik K Morozova Kateryna K Thangaswamy Sangeetha S Graves Austin A Kim Hei Jung HJ Li Tsai Wanxia TW Vigano' Marco M Soni Rajesh K RK Gadina Massimo M Tse Harley Y HY Galluzzi Lorenzo L Roche Paul A PA Denzin Lisa K LK Stern Lawrence J LJ Santambrogio Laura L
Immunity 20210315 4
Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes (T2D) and related mouse models. One dysmetabolic biochemical consequence is the non-enzymatic reaction between sugars, lipids, and proteins, favoring protein glycation, glycoxidation, and lipoxidation. Here, we identified oxidative alterations in key components of the major histocompatibility complex (MHC) class II molecule antigen processing and presentation machinery in vivo under conditions of hyperglycem ...[more]