PP1 inhibition using 1E7-03 during Human Cytomegalovirus infection in foreskin fibroblasts

ABSTRACT: Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins in its tegument layer for a rapid supply upon infection. However, the biological relevance behind PP1 incorporation and release upon infection is unclear. Additionally, PP1 is a difficult molecular target due to its promiscuity and similarities between the catalytic domain of multiple phosphatases. In this study, we circumvented these shortcomings by using 1E7-03, a small molecule protein-protein interaction inhibitor, as a molecular tool of noncatalytic PP1 inhibition in CMV infection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin, Fibroblast

SUBMITTER: Carmen Stecher  

LAB HEAD: Christoph Steininger

PROVIDER: PXD023598 | Pride | 2021-06-03

REPOSITORIES: Pride