Proteomics

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Investigation of region specific lipid alterations in symptomatic atherosclerotic plaques using mass spectrometry imaging

ABSTRACT: Atherosclerotic plaques are composed by different cell populations that interact one with each other in a complex and heterogeneous environment. Here we report a MALDI mass spectrometry imaging investigation of the lipid profile of specific plaque regions, to discriminate between symptomatic and asymptomatic atheromas. Regions were defined by histologic staining and immunofluorescence of consecutive tissue sections.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Atherosclerosis

SUBMITTER: Francesco Greco  

LAB HEAD: Liam Andrew McDonnell

PROVIDER: PXD023663 | Pride | 2021-09-10

REPOSITORIES: Pride

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Publications

Mass Spectrometry Imaging as a Tool to Investigate Region Specific Lipid Alterations in Symptomatic Human Carotid Atherosclerotic Plaques.

Greco Francesco F   Quercioli Laura L   Pucci Angela A   Rocchiccioli Silvia S   Ferrari Mauro M   Recchia Fabio A FA   McDonnell Liam A LA  

Metabolites 20210418 4

Atherosclerosis is characterized by fatty plaques in large and medium sized arteries. Their rupture can causes thrombi, occlusions of downstream vessels and adverse clinical events. The investigation of atherosclerotic plaques is made difficult by their highly heterogeneous nature. Here we propose a spatially resolved approach based on matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging to investigate lipids in specific regions of atherosclerotic plaques. The method was  ...[more]

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