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Profiling of the human Fallopian tube matrisome

ABSTRACT: Characterization of the protein composition of the extracellular matrix (ECM) of normal human Fallopian tube samples.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oviduct

SUBMITTER: Alexandra Naba

LAB HEAD: Alexandra Naba

PROVIDER: PXD023707 | Pride | 2021-11-02

REPOSITORIES: Pride

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Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas.

Renner Carine C Gomez Clarissa C Visetsouk Mike R MR Taha Isra I Khan Aisha A McGregor Stephanie M SM Weisman Paul P Naba Alexandra A Masters Kristyn S KS Kreeger Pamela K PK

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20211205 2

Recent evidence supports the fimbriae of the fallopian tube as one origin site for high-grade serous ovarian cancer (HGSOC). The progression of many solid tumors is accompanied by changes in the microenvironment, including alterations of the extracellular matrix (ECM). Therefore, we sought to determine the ECM composition of the benign fallopian tube and changes associated with serous tubal intraepithelial carcinomas (STICs), precursors of HGSOC. The ECM composition of benign human fallopian tub ...[more]

PMID: 34866441

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