Dataset Information
A proteomic analysis of livers from RagAGTP mice
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: 
Fernando Garcia
LAB HEAD: Javier Muñoz Peralta
PROVIDER: PXD023735 | Pride | 2021-06-21
REPOSITORIES: Pride
Publications
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.
Nature communications 20210616 1
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (expression of GTP-locked RagA, or RagA<sup>GTP</sup>) in mice resulted in a fatal energetic crisis at birth. Herein, we rescue neonatal lethality in RagA<sup>GTP</sup> mice and find morphometric and metabolic alterations that span glucose, lipid, ketone ...[more]
