Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Drosophila Virilis
SUBMITTER: Ignasi Forne
LAB HEAD: Prof Peter B. Becker
PROVIDER: PXD023747 | Pride | 2021-06-23
REPOSITORIES: Pride
Villa Raffaella R Jagtap Pravin Kumar Ankush PKA Thomae Andreas W AW Campos Sparr Aline A Forné Ignasi I Hennig Janosch J Straub Tobias T Becker Peter B PB
Genes & development 20210617 13-14
The dosage compensation complex (DCC) of <i>Drosophila</i> identifies its X-chromosomal binding sites with exquisite selectivity. The principles that assure this vital targeting are known from the <i>D. melanogaster</i> model: DCC-intrinsic specificity of DNA binding, cooperativity with the CLAMP protein, and noncoding roX2 RNA transcribed from the X chromosome. We found that in <i>D. virilis</i>, a species separated from <i>melanogaster</i> by 40 million years of evolution, all principles are a ...[more]