Proteomics

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Quantitative Proteomics Reveals Dormancy Related Proteins Mediated Attenuation Program in Mycobacterium Strain


ABSTRACT: To better understand the virulence difference among different MTB strains and identify new targets for therapeutic intervention under hypoxia condition, we compared the global protein expression at the protein level by quantitative proteomics among H37Rv, H37Ra and BCG.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mycobacterium Tuberculosis H37rv

SUBMITTER: Sun jinshuai  

LAB HEAD: Ping Xu

PROVIDER: PXD023788 | Pride | 2022-04-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20210123_MTB_TMT10_1.raw Raw
20210123_MTB_TMT10_10.raw Raw
20210123_MTB_TMT10_2.raw Raw
20210123_MTB_TMT10_3.raw Raw
20210123_MTB_TMT10_4.raw Raw
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Publications

Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains.

Wang Hong H   Wan Li L   Shi Jiahui J   Zhang Tao T   Zhu Huiming H   Jiang Songhao S   Meng Shuhong S   Wu Shujia S   Sun Jinshuai J   Chang Lei L   Zhang Liqun L   Wan Kanglin K   Yang Jiaqi J   Zhao Xiuqin X   Liu Haican H   Zhang Yao Y   Dai Erhei E   Xu Ping P  

Virulence 20211201 1


Although members of the <i>Mycobacterium tuberculosis</i> complex (MTBC) exhibit high similarity, they are characterized by differences with respect to virulence, immune response, and transmissibility. To understand the virulence of these bacteria and identify potential novel therapeutic targets, we systemically investigated the total cell protein contents of virulent H37Rv, attenuated H37Ra, and avirulent <i>M. bovis</i> BCG vaccine strains at the log and stationary phases, based on tandem mass  ...[more]

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