Proteomics

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Proteomic and functional analysis identifies proteins related to embryonic development in decidua of patients with early recurrent miscarriage


ABSTRACT: Recurrent miscarriage (RM) is the occurrence of repeated pregnancies that end in miscarriage of the fetus before 20 weeks of gestation. Recurrent miscarriages affect about 1-2% of couples trying to conceive; however, mechanisms leading to this complication are largely unknown. Our previous studies using comparative proteomics identified 314 differentially expressed proteins (DEPs) in placental villous. In this study, we identified 5479 proteins from a total of 34157 peptides in decidua of patients with early recurrent miscarriage. Further analysis identified 311 DEPs in the decidua tissue; 159 proteins showed the increased expression while 152 proteins showed decreased expression. These 311 proteins were further analyzed using Ingenuity Pathway Analysis (IPA). The results suggested that 50 DEPs could play important roles in the embryonic development. Furthermore, network analysis of the placental villous and decidua embryonic development DEPs was performed in STRING database to find the core gene. This study identifies several proteins that are specifically associated with embryonic development in decidua of patients with early recurrent miscarriage, these results provide new insights into potential biological mechanisms and may ultimately inform recurrent miscarriage.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Decidua

SUBMITTER: Hai-Tao Pan  

LAB HEAD: Hai-Tao Pan

PROVIDER: PXD023849 | Pride | 2021-07-30

REPOSITORIES: Pride

Dataset's files

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BP19337_F1.raw Raw
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Publications

Proteomic and functional analysis of proteins related to embryonic development of decidua in patients with recurrent pregnancy loss†.

Xiong Yi-Meng YM   Pan Hai-Tao HT   Ding Hai-Gang HG   He Yao Y   Zhang Juan J   Zhang Feng F   Yu Bin B   Zhang Tao T   Huang He-Feng HF  

Biology of reproduction 20211101 5


Recurrent pregnancy loss (RPL) is defined as the loss of two or more consecutive pregnancies before the 20 weeks of gestation. RPL affects about 1-2% of couples trying to conceive; however, the mechanisms leading to this complication are largely unknown. Our previous studies using comparative proteomics identified 314 differentially expressed proteins (DEPs) in the placental villous. In this study, we identified 5479 proteins from a total of 34 157 peptides in decidua of patients with early RPL  ...[more]

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