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ITRAQ quantitative analysis for AIS study

ABSTRACT: Relative quantitative analysis was performed to compare the proteomic profiles in plasma samples between healthy control and AIS subjects with different risk of curve progression.

INSTRUMENT(S): Q TRAP

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Yujia Wang

LAB HEAD: Wayne YW Lee

PROVIDER: PXD023915 | Pride | 2022-02-16

REPOSITORIES: Pride

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Publications

Potential Muscle-Related Biomarkers in Predicting Curve Progression to the Surgical Threshold in Adolescent Idiopathic Scoliosis-A Pilot Proteomic Study Comparing Four Non-Progressive vs. Four Progressive Patients vs. A Control Cohort.

Wang Yujia Y Chen Huanxiong H Zhang Jiajun J Lam Tsz-Ping TP Hung A L H ALH Cheng J C Y JCY Lee W Y W WYW

Journal of clinical medicine 20211025 21

Previous studies have reported abnormal muscle morphology and functions in patients with adolescent idiopathic scoliosis (AIS). To answer whether such abnormalities could be reflected in their circulation and their clinical implication for predicting curve progression to the surgical threshold, this preliminary study explored the presence of baseline muscle-related proteins and their association with curve progression. Plasma samples were collected at the first clinical visit for AIS, with patie ...[more]

PMID: 34768447

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