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Chicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides

ABSTRACT: Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer decisive resistance or susceptibility to many viruses. Examples are Marek's disease virus (MDV) and Infectious bursal disease virus (IBDV). We used a new in vitro infection system and immunopeptidomics to identify peptides presented to T lymphocytes via classical MHC class II molecules.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Primary Cell, Cell Suspension Culture

SUBMITTER: Michael Ghosh

LAB HEAD: Stefan Stevanovic

PROVIDER: PXD023954 | Pride | 2021-09-10

REPOSITORIES: Pride

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The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.

Halabi Samer S Ghosh Michael M Stevanović Stefan S Rammensee Hans-Georg HG Bertzbach Luca D LD Kaufer Benedikt B BB Moncrieffe Martin C MC Kaspers Bernd B Härtle Sonja S Kaufman Jim J

PLoS biology 20210426 4

Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer decisive resistance or susceptibility to many viral diseases. An iconic example is Marek's disease, caused by an oncogenic herpesvirus with over 100 genes. Classical MHC class I and class II molecule ...[more]

PMID: 33901176

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