The phosphorylation of the Smad2/3 linker region by Nemo-like kinase regulates TGF-β signaling

ABSTRACT: Smad2 and Smad3 (Smad2/3) primarily mediates the transforming growth factor-β (TGF-β) signaling that drives cell proliferation, differentiation, and migration. The dynamics of the Smad2/3 phosphorylation provides the key mechanism for regulating the TGF-β signaling pathway. Here we identified NLK as a novel regulator of TGF-β signaling pathway via modulating the phosphorylation of Smad2/3 in the linker region.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Yanchi Zhou  

LAB HEAD: Wei Song

PROVIDER: PXD023957 | Pride | 2021-09-10

REPOSITORIES: Pride