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Exosome proteomics under hypoxia

ABSTRACT: TMT multiplexed exosome samples, SEC purified from cells cultured under Normoxia and Hypoxia

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Kevin Klann

LAB HEAD: Christian Münch

PROVIDER: PXD024044 | Pride | 2021-09-10

REPOSITORIES: Pride

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Publications

Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells.

Geßner Alec A Koch Benjamin B Klann Kevin K Fuhrmann Dominik C DC Farmand Samira S Schubert Ralf R Münch Christian C Geiger Helmut H Baer Patrick C PC

International journal of molecular sciences 20210312 6

Cell-free therapy using extracellular vesicles (EVs) from adipose-derived mesenchymal stromal/stem cells (ASCs) seems to be a safe and effective therapeutic option to support tissue and organ regeneration. The application of EVs requires particles with a maximum regenerative capability and hypoxic culture conditions as an in vitro preconditioning regimen has been shown to alter the molecular composition of released EVs. Nevertheless, the EV cargo after hypoxic preconditioning has not yet been co ...[more]

PMID: 33808970

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