Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Cardiac Muscle Cell
DISEASE(S): Myocardial Ischemia
SUBMITTER: Carine Froment
LAB HEAD: Anne-Catherine Prats
PROVIDER: PXD024067 | Pride | 2023-01-03
REPOSITORIES: Pride
Godet Anne-Claire AC Roussel Emilie E David Florian F Hantelys Fransky F Morfoisse Florent F Alves Joffrey J Pujol Françoise F Ader Isabelle I Bertrand Edouard E Burlet-Schiltz Odile O Froment Carine C Henras Anthony K AK Vitali Patrice P Lacazette Eric E Tatin Florence F Garmy-Susini Barbara B Prats Anne-Catherine AC
eLife 20221222
Internal ribosome entry sites (IRESs) drive translation initiation during stress. In response to hypoxia, (lymph)angiogenic factors responsible for tissue revascularization in ischemic diseases are induced by the IRES-dependent mechanism. Here, we searched for IRES <i>trans</i>-acting factors (ITAFs) active in early hypoxia in mouse cardiomyocytes. Using knock-down and proteomics approaches, we show a link between a stressed-induced nuclear body, the paraspeckle, and IRES-dependent translation. ...[more]