Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain Microvascular Endothelial Cell
SUBMITTER: Fiorella Andrea Solari
LAB HEAD: Prof. Dr Albert Sickmann sickmann@isas.de>
PROVIDER: PXD024106 | Pride | 2022-10-14
REPOSITORIES: Pride
Basic research in cardiology 20220829 1
Antidepressants have been reported to enhance stroke recovery independent of the presence of depressive symptoms. They have recently been proposed to exert their mood-stabilizing actions by inhibition of acid sphingomyelinase (ASM), which catalyzes the hydrolysis of sphingomyelin to ceramide. Their restorative action post-ischemia/reperfusion (I/R) still had to be defined. Mice subjected to middle cerebral artery occlusion or cerebral microvascular endothelial cells exposed to oxygen-glucose dep ...[more]